Dtsch Tierarztl Wochenschr. Diagnosis is … Plasma [Pi] at Ti was furthermore corrected for the change in plasma [TP] on a percent basis occurring between T0 and Ti as described earlier.12 This approach was used to assess changes of plasma volume that may have occurred during the observation and may have affected the plasma [Pi] or [Mg]. The plasma [Pi]‐time curve of group MgP revealed a very flat increase with values differing from baseline only after 300 minutes and a Pi‐Tmax of 860 minutes with a maximum plasma [Pi] increment of 3.19 mg/dL (1.03 mmol/L, Table 1). Phosphate is an electrolyte (mineral) that works with calcium to help build bones. 1. Use the link below to share a full-text version of this article with your friends and colleagues. During lactation, the NRC 2001 guidelines recommends to feed diets with 0.3 – 0.4% of phosphorus in a dry matter (DM) basis. Twelve clinically healthy Holstein Friesian cows in their fourth week of lactation were used for this study. C, control, MgP, treatment with MgHPO4, NaP, treatment with NaH2PO4, Na2P, treatment with Na2HPO4. Learn about our remote access options, Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany, Department of Farm Animal Health, Utrecht University, Utrecht, The Netherlands, Funding information: ZuivelNL, the Netherlands. Working off-campus? Total protein concentration ([TP]) was measured by refractometry using a temperature corrected refractometer. Little information is available about the differences in efficacy between salts used for oral phosphorus supplementation. 22,39 For hematologic analysis, samples must be collected in tubes coated with anticoagulant agents, preferably potassium–ethylenediamine tetra-acetic acid (EDTA/K3) … Number of times cited according to CrossRef: Liver phosphorus content and liver function in states of phosphorus deficiency in transition dairy cows, https://en.wikipedia.org/wiki/Disodium_phosphate, https://en.wikipedia.org/wiki/Monosodium_phosphate, https://de.wikipedia.org/wiki/Natriumdihydrogenphosphate, https://de.wikipedia.org/wiki/Magnesiumhydrogenphosphat, area under the concentration‐time curve of plasma phosphate, CONTROL (denomination of treatment group), peak concentration of plasma phosphate derived from a model, peak concentration of plasma phosphate increment, peak concentration of plasma phosphate increment derived from a model, time to peak concentration of plasma phosphate, time to peak concentration of plasma phosphate derived from a model, Values with different superscript letters within a row were significantly different (. Significant effects were apparent within 1 hour (NaH2PO4: P = .0044; Na2HPO4: P = .0077). Hypophosphataemia may be asymptomatic, but clinical symptoms usually become apparent when plasma phosphate concentrations fall below 0.3mmol/L. ΔPi‐Cmax‐model and Pi‐Tmax‐model were then derived from the respective functions for each treatment group. After oral treatment of markedly phosphorus deficient cows with 1 of 3 different Pi containing salts (NaH2PO4, Na2HPO4, or MgHPO4) the increase in plasma [Pi] was most pronounced in group NaP, followed by Na2P. Although the plasma [Pi] in group NaP was numerically higher than in Na2P at various time points the difference was not significant at any time. The daily milk yield during the experimental treatment period ranged between 25 and 32 kg/day, daily feed intake ranged between 13 and 18 kg DM. Passive absorption is largely dependent on the phosphorus content … 1 It not only has been linked to decreased feed intake and productivity but is also believed to cause or contribute to periparturient conditions of the dairy cow such as the downer cow syndrome or postparturient hemoglobinuria. A statistical software package was used for all analyses (SAS 9.2; SAS Institute, Cary, North Carolina). The main objective of the present study was to compare the efficacy of different Pi containing salts for the treatment of hypophosphatemia in dairy cows. First in most countries of the world there are no commercial Pi‐containing solutions available that are labeled for the parenteral use in farm animals, making this approach an off‐label treatment. Diagnosis is … Post hoc tests were used whenever F‐test was significant. The most severe cellular damage seems to occur when there is concurrent phosphate depletion. { Hypophosphatemia is a serum phosphate concentration < 2.5 mg/dL (0.81 mmol/L). } Nonetheless, cow phosphorous requirement during the last trimester of gestation increases drastically. Phosphate is an electrolyte that helps your body with energy production and … All cows included in the study presented pronounced hypophosphatemia immediately before treatment (NaP: 1.27 mg/dL [0.41 mmol/L], Na2P: 1.38 mg/dL [0.45 mmol/L], MgP: 1.44 mg/dL [0.47 mmol/L], C: 1.30 mg/dL [0.42 mmol/L]), which is notably beneath reference range of 4–8 mg/dL or 1.4‐2.6 mmol/L.13 Baseline plasma [Pi] did not differ between groups. For this reason, phosphorus deficiency and hypophosphatemia incidence in dairy cows are more common during the transition period. It is probable that this difference between studies is attributable to the much more pronounced hypophosphatemia in this study that was achieved through a considerably longer duration of dietary P‐depletion. In order to delineate among the causes, it is important to obtain a thorough history, physical examination, and laboratory evaluation. Possible symptoms include: weakness, anorexia, malaise, tremor, paraesthesia, seizures, acute respiratory failure, arrhythmias, altered mental status and hypotension. Familial hypophosphatemia is a term encompassing a group of genetic diseases that impair homeostatic pathways of phosphate in the body. If you do not receive an email within 10 minutes, your email address may not be registered, Causes include alcohol use disorder, burns, starvation, and diuretic use. The Pi‐Tmax was 420 and 360 minutes after treatment with a peak increment of 5.33 mg/dL (1.72 mmol/L) and 4.30 mg/dL (1.39 mmol/L) in group NaP and Na2P, respectively (Table 1). The addressed question is relevant as the expectation of an oral treatment with Pi‐salts to rapidly correct acute hypophosphatemia in cows is inherently different from the use of Pi‐salts used as feed additives to supplement P‐deficient diets. The national and institutional guidelines for the care and use of experimental animals were followed and all experimental procedures were approved by the Utrecht University Institutional Animal Care and Use Committee (AVD108002016616). Comparison of efficacy of oral administration of NaH2PO4, Na2HPO4, and MgHPO4 in treating hypophosphatemia in cattle. There is also a trend towards the use of lower phosphorus crops being fed to cattle. It has been reported that phosphorus accretion in fetus (fetal fluids and membranes) and uterine tissues increases from 1.9g/day at 190 to 5.4g/d at 280 days of gestation, respectively. 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