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genetic risk factors for periodontal disease

For the last 20 years, the periodontal community has followed the classification of two distinct phenotypes of periodontitis: aggressive periodontitis (AgP) and chronic periodontitis (CP). • Risk indicator is used to describe a putative (or potential) risk factor identified to be associated with disease from case control or cross-sectional studies, but not yet confirmed in longitudinal or interventional studies. Risk Factors of Periodontal Disease: Review of the Literature Yousef A. AlJehani Dental Health Department, Colleg e of Applied Medical Sciences, K ing Saud University, P .O. Periodontitis is a multifactorial inflammatory disease and both environmental and genetic factors play a major role in the progression of the disease with consequent tissue destruction around the dental roots, and alveolar bone is associated with systemic alterations such as diabetes , changes in the liver , cardiovascular diseases , and even osteoporosis . Genetics. Periodontal disease is a complex infectious disease resulting from interplay of bacterial infection and host response to bacterial challenge, and the disease is modified by environmental, acquired risk factors and genetic susceptibility. DEFINITION 2.1. chronic inflammatory conditions of the gingiva, bone and ligament supporting the teeth 3. Data . The aims of this chapter are two-fold: first, to outline the key aspects of history taking in child, adolescent and young adult patients with periodontal problems; and secondly, to identify the principal systemic periodontal risk factors in these age groups that may be identified from the history. Risk factors for periodontal diseases include microbiologic factors, immunologic factors, environmental factors, and genetic factor. Smoking dries the mouth, which is an attractive environment for harmful bacteria. These factors can increase your risk of periodontal disease or make it worse once the infection has set in. Genetic risk factor’s for Periodontal Disease Could my periodontal disease be genetic? K eyWoRDs : Aggressive, chronic, genetic, gingivitis, periodontitis, polymorphism, single nucleotide, syndrome Periodontal diseases are multi-factorial, meaning that susceptibility to the disease involves genetic as well as environmental factors such as diet, smoking, and other lifestyle factors. J Clin Periodontol. In analyses not accounting for genetic factors, participants with advanced periodontal disease at baseline had a higher incidence of total cancer compared with those without periodontal disease (hazard ratio (HR) = 1.48, 95% confidence interval (CI): 1.30, 1.69). • A risk predictor/marker although associated with increased risk for disease, do not cause the disease. PERIODONTAL DISEASE by poofclam - 1. These responses are influenced by local, systemic, genetic and environmental risk factors. Gingivitis is a reversible condition whereas periodontitis is irreversible condition, in which along with inflammation of gingiva, destruction of tooth-supporting structure occurs. These risk factors are modifiable and their management is a major component of the contemporary care of many periodontal patients. Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. PATHOPHYSIOLOGY 3.1. dental plaque 3.2. microbial biofilm 3.3. immunopathogenesis • Genetic factors play a role in defining risk (Heritability estimated at about 30%) • Using the candidate gene approach, only a handful of polymorphisms have been validated in other studies (e.g., IL-1, IL-6, FcγR) • GWAS have not validated previous SNP associations (above) – Risk associated with any one variant likely small, ORs < 2 Smoking/Vaping: This is the strongest environmental risk factor for periodontal disease. 2005; 32 Suppl 6: 159-179. ... Genetic tests are done to determine the susceptibility of a person to the gum disease. In fact, recent studies have shown that tobacco use may be one of the most significant risk factors and smokers are three times more likely to develop periodontal disease compared with non-smokers. Several studies indicate that may persons have a predisposal to gum disease. Although previous research has demonstrated an association between coronary artery disease and periodontal disease due to risk factors such as diabetes, there weren’t many that compared their genetic … Periodontal disease increases with age; 70.1% of adults 65 years and older have periodontal disease” (CDC, 2015). 12.Michalowicz BS. Genetic factors also play a role in periodontal disease and allow one to target individuals for prevention and early detection. Within the domain of genetic risk factors for periodontitis, not only do certain genetic variations play a role, epigenetic changes in DNA are also involved. Identification of genetic risk factors for periodontitis and possible mechanisms of action. Genetics: Genetic risk factors influence one’s susceptibility and progression of gum disease. This disease usually starts out as gingivitis, which is characterized by … Risk factors of the gum disease ... medicines and medical condition of the person can also trigger gum disease. Role of plaque in periodontal disease Microbiology of periodontal disease One half of these individuals will develop the advanced stages of periodontal disease. Genetic factors and periodontal disease 1. Periodontal disease was also significantly associated with an increased risk of prostate cancer in men and with cancer of the corpus uteri in women. 1,2. The most common risk factors for developing gum disease are: Genetic factors. During the event, he revealed that both diseases share a genetic basis involving the VAMP8 function. In fact, most of the risk factors for gum disease are within your control. RISK FACTORS 1.1. cigarette smoking 1.2. diabetes mellitus 1.3. low education attainment 1.4. genetic predispositions 2. T he purpose of this paper is to review current knowledge of genetic risk factors for the periodontal diseases and to present updated and additional data from the Minnesota Twin Periodontal Study. Additional information from new technologies, such as micro-arrays and DNA-sequencing, should contribute to the identification of specific genetic, environmental, and behavioral factors that influence periodontitis susceptibility. Sources . Start studying PER 712 Risk factors for periodontal diseases: genetics. There are a number of risk factors for gum disease, but smoking is the most significant. Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. According to the American Dental Association, genetics is a risk factor for developing gum disease. Chapter 3 History and Systemic Risk Factors for Periodontal Diseases Aims . Genetic factors and heritable risk factors in periodontal disease: Highly sophisticated DNA analysis techniques have recently demonstrated that the transmission among family members can and does occur . Genetic and heritable risk factors in periodontal disease. Research proves that up to 30% of the population may be genetically susceptible to gum disease. The purpose of this paper is to review current knowledge of genetic risk factors for the periodontal diseases and to present updated and additional data from the Minnesota Twin Periodontal Study. Your genes play a major role in the onset and severity of periodontal diseases. Implants in function for a significant number years can develop peri-implantitis. Almost 70% of patients who have periodontal disease are smokers, current or past. 1 The risk factors for periodontal diseases can be broadly classified as individual and local. Systemic risk factors and risk indicators for periodontal disease • Systemic risk factors include smoking, diabetes mellitus, race, genetic factors, male gender, polymorphonuclear (PMN) functional abnormalities, low economic status, low educational level, acquired systemic infections such as human immunodeficiency virus (HIV), and severe malnutrition ( Table 11.1 ). Table 1. Other risk factors include diabetes; hormonal changes in girls and women; diabetes; medications that lessen the flow of saliva; certain illnesses, such as AIDS, and their medications; and genetic susceptibility. Instead, environmental effects, including oral hygiene and regular dental visits , still play the primary role in determining overall risk. But first, let’s discuss the risk factors that are not within your control. Many people are born with a “sensitivity” to plaque bacteria – making their periodontal disease much worse due… Learn vocabulary, terms, and more with flashcards, games, and other study tools. on genetic risk factors and its influence for the various forms of periodontal disease. Individuals with periodontal disease had an increased risk of lung cancer; however, after adjustment for smoking and other risk factors, this association was no longer statistically significant. J Periodontol. Table 1 provides a simple classification system for these factors. This paper aims to review the evidence on the potential roles of modifiable and nonmodifiable risk factors associated with periodontal disease. INTRODUCTION Bacteria cause periodontal disease, but other factors determine how severe that disease will become and how specific a patient responds to the therapy. The role of genetic factors in aggressive periodontitis is clear. If you have a family history of gum disease, then you are more likely to have problems with your gums. 11.Loos BG, John RP, Laine ML. Gingivitis is the inflammation of gingiva. Objectives . The reason is that some risk factors for gum disease relate more to behavior than genetics or overall health. The numbers were significant in finding and led the authors to further research the linkage between factors such as genetics and epigenetics and susceptibility to periodontitis. 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